Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through inter...
Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics
About this item
Full title
Author / Creator
Dans, Madeline G. , Piirainen, Henni , Nguyen, William , Khurana, Sachin , Mehra, Somya , Razook, Zahra , Geoghegan, Niall D. , Dawson, Aurelie T. , Das, Sujaan , Parkyn Schneider, Molly , Jonsdottir, Thorey K. , Gabriela, Mikha , Gancheva, Maria R. , Tonkin, Christopher J. , Mollard, Vanessa , Goodman, Christopher Dean , McFadden, Geoffrey I. , Wilson, Danny W. , Rogers, Kelly L. , Barry, Alyssa E. , Crabb, Brendan S. , de Koning-Ward, Tania F. , Sleebs, Brad E. , Kursula, Inari and Gilson, Paul R.
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target
Plasmodium falciparum
. We have recently described a compound, MMV020291, as a specific inhibitor of red blood cell (RBC) invasion, and have generated analogues with improved potency. Here, we generated resistance to MMV020291 an...
Alternative Titles
Full title
Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics
Authors, Artists and Contributors
Author / Creator
Piirainen, Henni
Nguyen, William
Khurana, Sachin
Mehra, Somya
Razook, Zahra
Geoghegan, Niall D.
Dawson, Aurelie T.
Das, Sujaan
Parkyn Schneider, Molly
Jonsdottir, Thorey K.
Gabriela, Mikha
Gancheva, Maria R.
Tonkin, Christopher J.
Mollard, Vanessa
Goodman, Christopher Dean
McFadden, Geoffrey I.
Wilson, Danny W.
Rogers, Kelly L.
Barry, Alyssa E.
Crabb, Brendan S.
de Koning-Ward, Tania F.
Sleebs, Brad E.
Kursula, Inari
Gilson, Paul R.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2814430521
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2814430521
Other Identifiers
ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.3002066
