CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development...
CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Synonymous recoding of RNA virus genomes is a promising approach for generating attenuated viruses to use as vaccines. Problematically, recoding typically hinders virus growth, but this may be rectified using CpG dinucleotide enrichment. CpGs are recognised by cellular zinc-finger antiviral protein (ZAP), and so in principle, removing ZAP sensing f...
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Full title
CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy
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TN_cdi_plos_journals_2826806064
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2826806064
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1011357
