Characterisation of putative class 1A DHODH-like proteins from Mucorales and dematiaceous mould spec...
Characterisation of putative class 1A DHODH-like proteins from Mucorales and dematiaceous mould species
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Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Olorofim is a new antifungal in clinical development which has a novel mechanism of action against dihydroorotate dehydrogenase (DHODH). DHODH form a ubiquitous family of enzymes in the
de novo
pyrimidine biosynthetic pathway and are split into class 1A, class 1B and class 2. Olorofim specifically targets the fungal class 2 DHODH present in a...
Alternative Titles
Full title
Characterisation of putative class 1A DHODH-like proteins from Mucorales and dematiaceous mould species
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TN_cdi_plos_journals_2845067104
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2845067104
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0289441
