Gene regulation analysis of patient-derived iPSCs and its CRISPR-corrected control provides a new to...
Gene regulation analysis of patient-derived iPSCs and its CRISPR-corrected control provides a new tool for studying perturbations of ELMOD3 c.512A>G mutation during the development of inherited hearing loss
About this item
Full title
Author / Creator
Liu, Xianlin , Wen, Jie , Liu, Xuezhong , Chen, Anhai , Li, Sijun , Liu, Jing , Sun, Jie , Gong, Wei , Kang, Xiaoming , Feng, Zhili , He, Chufeng , Mei, Lingyun , Ling, Jie and Feng, Yong
Publisher
San Francisco: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
San Francisco: Public Library of Science
Subjects
More information
Scope and Contents
Contents
The
ELMOD3
gene is implicated in causing autosomal recessive/dominant non-syndromic hearing loss in humans. However, the etiology has yet to be completely elucidated. In this study, we generated a patient-derived iPSC line carrying
ELMOD3
c.512A>G mutation. In addition, the patient-derived iPSC line was corrected by CRISPR/Cas9 genome e...
Alternative Titles
Full title
Gene regulation analysis of patient-derived iPSCs and its CRISPR-corrected control provides a new tool for studying perturbations of ELMOD3 c.512A>G mutation during the development of inherited hearing loss
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2864887982
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2864887982
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0288640
