A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replicat...
A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo
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Author / Creator
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States) , Taha, Taha Y. , Suryawanshi, Rahul K. , Chen, Irene P. , Correy, Galen J. , McCavitt-Malvido, Maria , O’Leary, Patrick C. , Jogalekar, Manasi P. , Diolaiti, Morgan E. , Kimmerly, Gabriella R. , Tsou, Chia-Lin , Gascon, Ronnie , Montano, Mauricio , Martinez-Sobrido, Luis , Krogan, Nevan J. , Ashworth, Alan , Fraser, James S. and Ott, Melanie
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Despite unprecedented efforts, our therapeutic arsenal against SARS-CoV-2 remains limited. The conserved macrodomain 1 (Mac1) in NSP3 is an enzyme exhibiting ADP-ribosylhydrolase activity and a possible drug target. To determine the role of Mac1 catalytic activity in viral replication, we generated recombinant viruses and replicons encoding a catal...
Alternative Titles
Full title
A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo
Authors, Artists and Contributors
Author / Creator
Taha, Taha Y.
Suryawanshi, Rahul K.
Chen, Irene P.
Correy, Galen J.
McCavitt-Malvido, Maria
O’Leary, Patrick C.
Jogalekar, Manasi P.
Diolaiti, Morgan E.
Kimmerly, Gabriella R.
Tsou, Chia-Lin
Gascon, Ronnie
Montano, Mauricio
Martinez-Sobrido, Luis
Krogan, Nevan J.
Ashworth, Alan
Fraser, James S.
Ott, Melanie
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2865505918
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2865505918
Other Identifiers
ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1011614
