The V2 domain of HIV gp120 mimics an interaction between CD4 and integrin ⍺4β7
The V2 domain of HIV gp120 mimics an interaction between CD4 and integrin ⍺4β7
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Author / Creator
Van Ryk, Donald , Vimonpatranon, Sinmanus , Hiatt, Joe , Ganesan, Sundar , Chen, Nathalie , McMurry, Jordan , Garba, Saadiq , Min, Susie , Goes, Livia R. , Girard, Alexandre , Yolitz, Jason , Licavoli, Isabella , Wei, Danlan , Huang, Dawei , Soares, Marcelo A. , Martinelli, Elena , Cicala, Claudia and Arthos, James
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
The CD4 receptor, by stabilizing TCR-MHC II interactions, plays a central role in adaptive immunity. It also serves as the HIV docking receptor. The HIV gp120 envelope protein binds directly to CD4. This interaction is a prerequisite for viral entry. gp120 also binds to ⍺
4
β
7
, an integrin that is expressed on a subset of memory CD4
Alternative Titles
Full title
The V2 domain of HIV gp120 mimics an interaction between CD4 and integrin ⍺4β7
Authors, Artists and Contributors
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Record Identifier
TN_cdi_plos_journals_3069180189
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_3069180189
Other Identifiers
ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1011860
