A phase 2 open-label study of the safety and efficacy of weekly dosing of ATL1102 in patients with n...
A phase 2 open-label study of the safety and efficacy of weekly dosing of ATL1102 in patients with non-ambulatory Duchenne muscular dystrophy and pharmacology in mdx mice
About this item
Full title
Author / Creator
Woodcock, Ian R. , Tachas, George , Desem, Nuket , Houweling, Peter J. , Kean, Michael , Emmanuel, Jaiman , Kennedy, Rachel , Carroll, Kate , de Valle, Katy , Adams, Justine , Lamandé, Shireen R. , Coles, Chantal , Tiong, Chrystal , Burton, Matthew , Villano, Daniella , Button, Peter , Hogrel, Jean-Yves , Catling-Seyffer, Sarah , Ryan, Monique M. , Delatycki, Martin B. and Yiu, Eppie M.
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
ATL1102 is a 2'MOE gapmer antisense oligonucleotide to the CD49d alpha subunit of VLA-4, inhibiting expression of CD49d on lymphocytes, reducing survival, activation and migration to sites of inflammation. Children with DMD have dystrophin deficient muscles susceptible to contraction induced injury, which triggers the immune system, exacerbating mu...
Alternative Titles
Full title
A phase 2 open-label study of the safety and efficacy of weekly dosing of ATL1102 in patients with non-ambulatory Duchenne muscular dystrophy and pharmacology in mdx mice
Authors, Artists and Contributors
Author / Creator
Tachas, George
Desem, Nuket
Houweling, Peter J.
Kean, Michael
Emmanuel, Jaiman
Kennedy, Rachel
Carroll, Kate
de Valle, Katy
Adams, Justine
Lamandé, Shireen R.
Coles, Chantal
Tiong, Chrystal
Burton, Matthew
Villano, Daniella
Button, Peter
Hogrel, Jean-Yves
Catling-Seyffer, Sarah
Ryan, Monique M.
Delatycki, Martin B.
Yiu, Eppie M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_3069269495
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_3069269495
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0294847
