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The p53 protein is a suppressor of Atox1 copper chaperon in tumor cells under genotoxic effects

The p53 protein is a suppressor of Atox1 copper chaperon in tumor cells under genotoxic effects

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_3072931491

The p53 protein is a suppressor of Atox1 copper chaperon in tumor cells under genotoxic effects

About this item

Full title

The p53 protein is a suppressor of Atox1 copper chaperon in tumor cells under genotoxic effects

Publisher

United States: Public Library of Science

Journal title

PloS one, 2023-12, Vol.18 (12), p.e0295944-e0295944

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

The p53 protein is crucial for regulating cell survival and apoptosis in response to DNA damage. However, its influence on therapy effectiveness is controversial: when DNA damage is high p53 directs cells toward apoptosis, while under moderate genotoxic stress it saves the cells from death and promote DNA repair. Furthermore, these processes are in...

Alternative Titles

Full title

The p53 protein is a suppressor of Atox1 copper chaperon in tumor cells under genotoxic effects

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_3072931491

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_3072931491

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0295944

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