Extraneural infection route restricts prion conformational variability and attenuates the impact of...
Extraneural infection route restricts prion conformational variability and attenuates the impact of quaternary structure on infectivity
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Prions can exist as different strains that consist of conformational variants of the misfolded, pathogenic prion protein isoform PrP
Sc
. Defined by stably transmissible biological and biochemical properties, strains have been identified in a spectrum of prion diseases, including chronic wasting disease (CWD) of wild and farmed cervids. CWD i...
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Extraneural infection route restricts prion conformational variability and attenuates the impact of quaternary structure on infectivity
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TN_cdi_plos_journals_3086953509
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_3086953509
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1012370
