Structural insight into the DNMT1 reaction cycle by cryo-electron microscopy
Structural insight into the DNMT1 reaction cycle by cryo-electron microscopy
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Contents
DNMT1 is an essential DNA methyltransferase that catalyzes the transfer of methyl groups to CpG islands in DNA and generates a prominent epigenetic mark. The catalytic activity of DNMT1 relies on its conformational plasticity and ability to change conformation from an auto-inhibited to an activated state. Here, we present four cryo-EM reconstructio...
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Full title
Structural insight into the DNMT1 reaction cycle by cryo-electron microscopy
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TN_cdi_plos_journals_3100498003
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_3100498003
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0307850
