Integrated multi-omics approach revealed TTNtv c.13254T>G causing dilated cardiomyopathy in mice
Integrated multi-omics approach revealed TTNtv c.13254T>G causing dilated cardiomyopathy in mice
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Author / Creator
Yu, Dan , Tao, Liang , Song, Laichun , Lai, Kaisheng , Jiang, Hui , Liu, Zhe and Xiao, Hongyan
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Titin-truncating variant (
TTNtv
) is the most common genetic cause of dilated cardiomyopathy (DCM). In the previous study, we found a novel heterozygous
TTN
tv c.13254T>G (p.Tyr4418Ter) associated with DCM, but lacking functional evidence. The purpose of this study is to demonstrate the pathogenicity of
TTNtv
c.13254T>G. We const...
Alternative Titles
Full title
Integrated multi-omics approach revealed TTNtv c.13254T>G causing dilated cardiomyopathy in mice
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Record Identifier
TN_cdi_plos_journals_3113065012
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_3113065012
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0311670
