Intracerebroventricular administration of a modified hexosaminidase ameliorates late-stage neurodege...
Intracerebroventricular administration of a modified hexosaminidase ameliorates late-stage neurodegeneration in a GM2 mouse model
About this item
Full title
Author / Creator
Lopez, Manuel E. , Wendt, Daniel , Lawrence, Roger , Gong, Kerui , Ong, Hoonsan , Yip, Bryan , Chen, Joseph , Mangini, Linley , Handyside, Britta , Giaramita, Alexander , Lamichhane, Aashish , Lo, Melanie , Agrawal, Vishal , Van Vleet, Jeremy , Abolhesn, Amanda , Felix, Jessica B. , Villalpando, Isaac , Bhat, Vikas , De Angelis, Rolando , Ru, Yuanbin , Khan, Ayesha , Fong, Sylvia , Christianson, Terri , Bullens, Sherry , Crawford, Brett E. , Bunting, Stuart and Aoyagi-Scharber, Mika
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
The GM2 gangliosidoses, Tay-Sachs disease and Sandhoff disease, are devastating neurodegenerative disorders caused by β-hexosaminidase A (HexA) deficiency. In the Sandhoff disease mouse model, rescue potential was severely reduced when HexA was introduced after disease onset. Here, we assess the effect of recombinant HexA and HexD3, a newly enginee...
Alternative Titles
Full title
Intracerebroventricular administration of a modified hexosaminidase ameliorates late-stage neurodegeneration in a GM2 mouse model
Authors, Artists and Contributors
Author / Creator
Wendt, Daniel
Lawrence, Roger
Gong, Kerui
Ong, Hoonsan
Yip, Bryan
Chen, Joseph
Mangini, Linley
Handyside, Britta
Giaramita, Alexander
Lamichhane, Aashish
Lo, Melanie
Agrawal, Vishal
Van Vleet, Jeremy
Abolhesn, Amanda
Felix, Jessica B.
Villalpando, Isaac
Bhat, Vikas
De Angelis, Rolando
Ru, Yuanbin
Khan, Ayesha
Fong, Sylvia
Christianson, Terri
Bullens, Sherry
Crawford, Brett E.
Bunting, Stuart
Aoyagi-Scharber, Mika
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_3151369441
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_3151369441
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0315005
