Protective effect of Pinacidil on hypoxic-reoxygenated cardiomyocytes in vitro and in vivo via HIF-1...
Protective effect of Pinacidil on hypoxic-reoxygenated cardiomyocytes in vitro and in vivo via HIF-1α/HRE pathway
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Cardiomyocyte hypoxia-reoxygenation (HR) is considered as a major cause of heart failure. Pinacidil is a classic ATP sensitive potassium channel opener and plays a crucial role in cardiomyocyte HR injuries. However, the specific mechanism is poorly understood. We established HR rat model and introduced 5-Hydroxydecanoate (5-HD), N-(2-Mercaptopropio...
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Full title
Protective effect of Pinacidil on hypoxic-reoxygenated cardiomyocytes in vitro and in vivo via HIF-1α/HRE pathway
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TN_cdi_plos_journals_3170839624
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_3170839624
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0318859
