Natural Variation in Human Membrane Transporter Genes Reveals Evolutionary and Functional Constraint...
Natural Variation in Human Membrane Transporter Genes Reveals Evolutionary and Functional Constraints
About this item
Full title
Author / Creator
Leabman, Maya K. , Huang, Conrad C. , DeYoung, Joseph , Carlson, Elaine J. , Taylor, Travis R. , de la Cruz, Melanie , Johns, Susan J. , Stryke, Doug , Kawamoto, Michiko , Urban, Thomas J. , Kroetz, Deanna L. , Ferrin, Thomas E. , Clark, Andrew G. , Risch, Neil , Herskowitz, Ira , Giacomini, Kathleen M. , Pharmacogenetics of Membrane Transporters Investigators , Pharmacogenetics of Membrane Transporters Investigators and Pharmacogenetics Of Membrane Transporters Investigators
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
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More information
Scope and Contents
Contents
Membrane transporters maintain cellular and organismal homeostasis by importing nutrients and exporting toxic compounds. Transporters also play a crucial role in drug response, serving as drug targets and setting drug levels. As part of a pharmacogenetics project, we screened exons and flanking intronic regions for variation in a set of 24 membrane...
Alternative Titles
Full title
Natural Variation in Human Membrane Transporter Genes Reveals Evolutionary and Functional Constraints
Authors, Artists and Contributors
Author / Creator
Huang, Conrad C.
DeYoung, Joseph
Carlson, Elaine J.
Taylor, Travis R.
de la Cruz, Melanie
Johns, Susan J.
Stryke, Doug
Kawamoto, Michiko
Urban, Thomas J.
Kroetz, Deanna L.
Ferrin, Thomas E.
Clark, Andrew G.
Risch, Neil
Herskowitz, Ira
Giacomini, Kathleen M.
Pharmacogenetics of Membrane Transporters Investigators
Pharmacogenetics of Membrane Transporters Investigators
Pharmacogenetics Of Membrane Transporters Investigators
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pnas_primary_100_10_5896
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_100_10_5896
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0730857100
