The Lipoxygenase Gene ALOXE3 Implicated in Skin Differentiation Encodes a Hydroperoxide Isomerase
The Lipoxygenase Gene ALOXE3 Implicated in Skin Differentiation Encodes a Hydroperoxide Isomerase
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Lipoxygenase (LOX) enzymes form fatty acid hydroperoxides used in membrane remodeling and cell signaling. Mammalian epidermal LOX type 3 (eLOX3) is distinctive in totally lacking this typical oxygenase activity. Surprisingly, genetic evidence has linked mutations in eLOX3 or a colocalizing enzyme, 12R-LOX, to disruption of the normal permeability b...
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Full title
The Lipoxygenase Gene ALOXE3 Implicated in Skin Differentiation Encodes a Hydroperoxide Isomerase
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TN_cdi_pnas_primary_100_16_9162
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_100_16_9162
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1633612100
