Transcriptional Regulatory Cascades in Development: Initial Rates, Not Steady State, Determine Netwo...
Transcriptional Regulatory Cascades in Development: Initial Rates, Not Steady State, Determine Network Kinetics
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
A model was built to examine the kinetics of regulatory cascades such as occur in developmental gene networks. The model relates occupancy of cis-regulatory target sites to transcriptional initiation rate, and thence to RNA and protein output. The model was used to simulate regulatory cascades in which genes encoding transcription factors are succe...
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Full title
Transcriptional Regulatory Cascades in Development: Initial Rates, Not Steady State, Determine Network Kinetics
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Record Identifier
TN_cdi_pnas_primary_100_16_9371
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_100_16_9371
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1533293100
