A Glycopeptide in Complex with MHC Class I Uses the GalNAc Residue as an Anchor
A Glycopeptide in Complex with MHC Class I Uses the GalNAc Residue as an Anchor
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Peptides bind MHC class I molecules by anchoring hydrophobic side chains into pockets in the peptide binding groove. Here, we report an immunogenic (in vitro and in vivo) MUC1 glycopeptide (MUC1-8-5GalNAc) bound to H-2Kb, fully crossreactive with the nonglycosylated variant. Molecular modeling showed that the central P5-Thr-GalNAc residue points in...
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Full title
A Glycopeptide in Complex with MHC Class I Uses the GalNAc Residue as an Anchor
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TN_cdi_pnas_primary_100_25_15029_fulltext
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_100_25_15029_fulltext
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2432220100
