Infertility and Aneuploidy in Mice Lacking a Type IA DNA Topoisomerase IIIβ
Infertility and Aneuploidy in Mice Lacking a Type IA DNA Topoisomerase IIIβ
About this item
Full title
Author / Creator
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
We report that disruption of the mouse TOP3β gene encoding DNA topoisomerase IIIβ, one of the two mammalian type IA DNA topoisomerases, leads to a progressive reduction in fecundity. The litter size in crosses of top3β-/-mice decreases over time and through successive generations, and this decrease seems to reflect embryonic death rather than impai...
Alternative Titles
Full title
Infertility and Aneuploidy in Mice Lacking a Type IA DNA Topoisomerase IIIβ
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pnas_primary_100_5_2526
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_100_5_2526
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0437998100
