An Agonist-Induced Switch in G Protein Coupling of the Gonadotropin-Releasing Hormone Receptor Regul...
An Agonist-Induced Switch in G Protein Coupling of the Gonadotropin-Releasing Hormone Receptor Regulates Pulsatile Neuropeptide Secretion
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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The pulsatile secretion of gonadotropin-releasing hormone (GnRH) from normal and immortalized hypothalamic GnRH neurons is highly calcium-dependent and is stimulated by cAMP. It is also influenced by agonist activation of the endogenous GnRH receptor (GnRH-R), which couples to Gq/11as indicated by release of membrane-bound αq/11subunits and increas...
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Full title
An Agonist-Induced Switch in G Protein Coupling of the Gonadotropin-Releasing Hormone Receptor Regulates Pulsatile Neuropeptide Secretion
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TN_cdi_pnas_primary_100_5_2969
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_100_5_2969
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0535708100
