Hearing Loss and Retarded Cochlear Development in Mice Lacking Type 2 Iodothyronine Deiodinase
Hearing Loss and Retarded Cochlear Development in Mice Lacking Type 2 Iodothyronine Deiodinase
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
The later stages of cochlear differentiation and the developmental onset of hearing require thyroid hormone. Although thyroid hormone receptors (TRs) are a prerequisite for this process, it is likely that other factors modify TR activity during cochlear development. The mouse cochlea expresses type 2 deiodinase (D2), an enzyme that converts thyroxi...
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Full title
Hearing Loss and Retarded Cochlear Development in Mice Lacking Type 2 Iodothyronine Deiodinase
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TN_cdi_pnas_primary_101_10_3474_fulltext
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_101_10_3474_fulltext
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0307402101
