Identification and Modulation of a Caveolae-Dependent Signal Pathway That Regulates Plasminogen Acti...
Identification and Modulation of a Caveolae-Dependent Signal Pathway That Regulates Plasminogen Activator Inhibitor-1 in Insulin-Resistant Adipocytes
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Plasminogen activator inhibitor-1 (PAI-1) plays an important role in the pathogenesis of obesity-driven type 2 diabetes mellitus and associated cardiovascular complications. Here, we show that perturbation of caveolar microdomains leads to insulin resistance and concomitant up-regulation of PAI-1 in 3T3L1 adipocytes. We present several lines of evi...
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Full title
Identification and Modulation of a Caveolae-Dependent Signal Pathway That Regulates Plasminogen Activator Inhibitor-1 in Insulin-Resistant Adipocytes
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TN_cdi_pnas_primary_101_49_17120_fulltext
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_101_49_17120_fulltext
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0405278101
