Gene Targeting Using a Promoterless Gene Trap Vector ("Targeted Trapping") Is an Efficient Method to...
Gene Targeting Using a Promoterless Gene Trap Vector ("Targeted Trapping") Is an Efficient Method to Mutate a Large Fraction of Genes
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
A powerful tool for postgenomic analysis of mammalian gene function is gene targeting in mouse ES cells. We report that homologous recombination using a promoterless gene trap vector ("targeting trapping") yields targeting frequencies averaging above 50%, a significant increase compared with current approaches. These high frequencies appear to be d...
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Gene Targeting Using a Promoterless Gene Trap Vector ("Targeted Trapping") Is an Efficient Method to Mutate a Large Fraction of Genes
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TN_cdi_pnas_primary_102_37_13188_fulltext
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_102_37_13188_fulltext
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0505474102
