miR-15 and miR-16 Induce Apoptosis by Targeting BCL2
miR-15 and miR-16 Induce Apoptosis by Targeting BCL2
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Author / Creator
Cimmino, Amelia , Calin, George Adrian , Fabbri, Muller , Iorio, Marilena V. , Ferracin, Manuela , Shimizu, Masayoshi , Wojcik, Sylwia E. , Aqeilan, Rami I. , Zupo, Simona , Dono, Mariella , Rassenti, Laura , Alder, Hansjuerg , Volinia, Stefano , Liu, Chang-gong , Kipps, Thomas J. , Negrini, Massimo and Croce, Carlo M.
Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is characterized by predominantly nondividing malignant B cells overexpressing the antiapoptotic B cell lymphoma 2 (Bcl2) protein. miR-15a and miR-16-1 are deleted or down-regulated in the majority of CLLs. Here, we demonstrate that miR-15a and miR-16-1 expression is inversely...
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Full title
miR-15 and miR-16 Induce Apoptosis by Targeting BCL2
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Record Identifier
TN_cdi_pnas_primary_102_39_13944_fulltext
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_102_39_13944_fulltext
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0506654102
