The ER Aminopeptidase, ERAP1, Trims Precursors to Lengths of MHC Class I Peptides by a "Molecular Ru...
The ER Aminopeptidase, ERAP1, Trims Precursors to Lengths of MHC Class I Peptides by a "Molecular Ruler" Mechanism
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an IFN-γ-induced aminopeptidase in the endoplasmic reticulum that trims longer precursors to the antigenic peptides presented on MHC class I molecules. We recently reported that purified ERAP1 trimmed N-extended precursors but spared peptides of 8-9 residues, the length required for binding to MHC c...
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Full title
The ER Aminopeptidase, ERAP1, Trims Precursors to Lengths of MHC Class I Peptides by a "Molecular Ruler" Mechanism
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TN_cdi_pnas_primary_102_47_17107
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_102_47_17107
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0500721102
