Complex I Deficiency Primes Bax-Dependent Neuronal Apoptosis through Mitochondrial Oxidative Damage
Complex I Deficiency Primes Bax-Dependent Neuronal Apoptosis through Mitochondrial Oxidative Damage
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Dysfunction of mitochondrial complex I is a feature of human neurodegenerative diseases such as Leber hereditary optic neuropathy and Parkinson's disease. This mitochondrial defect is associated with a recruitment of the mitochondrial-dependent apoptotic pathway in vivo. However, in isolated brain mitochondria, complex I dysfunction caused by eithe...
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Full title
Complex I Deficiency Primes Bax-Dependent Neuronal Apoptosis through Mitochondrial Oxidative Damage
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TN_cdi_pnas_primary_102_52_19126_fulltext
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_102_52_19126_fulltext
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0508215102
