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Structure of the Kainate Receptor Subunit GluR6 Agonist-Binding Domain Complexed with Domoic Acid

Structure of the Kainate Receptor Subunit GluR6 Agonist-Binding Domain Complexed with Domoic Acid

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_102_5_1708_fulltext

Structure of the Kainate Receptor Subunit GluR6 Agonist-Binding Domain Complexed with Domoic Acid

About this item

Full title

Structure of the Kainate Receptor Subunit GluR6 Agonist-Binding Domain Complexed with Domoic Acid

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2005-02, Vol.102 (5), p.1708-1713

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

We report the crystal structure of the glycosylated ligand-binding (S1S2) domain of the kainate receptor subunit GluR6, in complex with the agonist domoate. The structure shows the expected overall homology with AMPA and NMDA receptor subunit structures but reveals an unexpected binding mode for the side chain of domoate, in which contact is made t...

Alternative Titles

Full title

Structure of the Kainate Receptor Subunit GluR6 Agonist-Binding Domain Complexed with Domoic Acid

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pnas_primary_102_5_1708_fulltext

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_102_5_1708_fulltext

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.0409573102

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