Targeted Gene Disruption of Methionine Aminopeptidase 2 Results in an Embryonic Gastrulation Defect...
Targeted Gene Disruption of Methionine Aminopeptidase 2 Results in an Embryonic Gastrulation Defect and Endothelial Cell Growth Arrest
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
The antiangiogenic agent fumagillin (Fg) and its analog TNP-470 bind to intracellular metalloprotease methionine aminopeptidase-2 (MetAP-2) and inhibit endothelial cell growth in a p53dependent manner. To confirm the role of MetAP-2 in endothelial cell proliferation and to validate it as a physiological target for the Fg class of antiangiogenic age...
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Full title
Targeted Gene Disruption of Methionine Aminopeptidase 2 Results in an Embryonic Gastrulation Defect and Endothelial Cell Growth Arrest
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Record Identifier
TN_cdi_pnas_primary_103_27_10379
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_103_27_10379
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0511313103
