Poly(ADP-Ribose) (PAR) Polymer Is a Death Signal
Poly(ADP-Ribose) (PAR) Polymer Is a Death Signal
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Excessive activation of the nuclear enzyme, poly(ADP-ribose) polymerase-1 (PARP-1) plays a prominent role in various of models of cellular injury. Here, we identify poly(ADP-ribose) (PAR) polymer, a product of PARP-1 activity, as a previously uncharacterized cell death signal. PAR polymer is directly toxic to neurons, and degradation of PAR polymer...
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Full title
Poly(ADP-Ribose) (PAR) Polymer Is a Death Signal
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TN_cdi_pnas_primary_103_48_18308_fulltext
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_103_48_18308_fulltext
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0606526103
