intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133
intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
The muscle-specific microRNAs, miR-1 and miR-133, play important roles in muscle growth and differentiation. Here, we show that the MEF2 transcription factor, an essential regulator of muscle development, directly activates transcription of a bicistronic primary transcript encoding miR-1-2 and 133a-1 via an intragenic muscle-specific enhancer locat...
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Full title
intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133
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TN_cdi_pnas_primary_104_52_20844
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_104_52_20844
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0710558105
