Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13
Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Proteolytic processing of von Willebrand factor (VWF) by ADAMTS13 metalloproteinase is crucial for normal hemostasis. In vitro, cleavage of VWF by ADAMTS13 is slow even at high shear stress and is typically studied in the presence of denaturants. We now show that, under shear stress and at physiological pH and ionic strength, coagulation factor VII...
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Full title
Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13
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TN_cdi_pnas_primary_105_21_7416_fulltext
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_105_21_7416_fulltext
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0801735105
