Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down...
Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome
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Author / Creator
Voronov, Sergey V , Frere, Samuel G , Giovedi, Silvia , Pollina, Elizabeth A , Borel, Christelle , Zhang, Hong , Schmidt, Cecilia , Akeson, Ellen C , Wenk, Markus R , Cimasoni, Laurent , Arancio, Ottavio , Davisson, Muriel T , Antonarakis, Stylianos E , Gardiner, Katheleen , De Camilli, Pietro and Di Paolo, Gilbert
Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P₂] is a signaling phospholipid implicated in a wide variety of cellular functions. At synapses, where normal PtdIns(4,5)P₂ balance is required for proper neurotransmission, the phosphoinositide phosphatase synaptojanin 1 is a key regulator of its metabolism. The underlying gene, SYNJ1, maps to huma...
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Full title
Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome
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Record Identifier
TN_cdi_pnas_primary_105_27_9415
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_105_27_9415
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0803756105
