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Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy:...

Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy:...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_105_41_15896

Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: Blockade of compensatory renin increase

About this item

Full title

Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: Blockade of compensatory renin increase

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2008-10, Vol.105 (41), p.15896-15901

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

The renin-angiotensin system (RAS) plays a critical role in the development of diabetic nephropathy, and blockade of the RAS is currently used for treatment of diabetic nephropathy. One major problem for the current RAS inhibitors is the compensatory renin increase, which reduces the efficacy of RAS inhibition. We have shown that vitamin D exerts r...

Alternative Titles

Full title

Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: Blockade of compensatory renin increase

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pnas_primary_105_41_15896

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_105_41_15896

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.0803751105

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