Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development
About this item
Full title
Author / Creator
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Pteridine reductase (PTR1) is essential for salvage of pterins by parasitic trypanosomatids and is a target for the development of improved therapies. To identify inhibitors of Leishmania major and Trypanosoma cruzi PTR1, we combined a rapid-screening strategy using a folate-based library with structure-based design. Assays were carried out against...
Alternative Titles
Full title
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pnas_primary_105_5_1448_fulltext
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_105_5_1448_fulltext
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0704384105
