Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41
Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
We have investigated the mechanism of resistance of a HIV type 1 (HIV-1) R5 primary isolate, D1/85.16, to the small molecule CCR5 inhibitor, vicriviroc (VVC). Unlike other viruses resistant to this class of compound, D1/85.16 lacks sequence changes in the V3 region of the gp120 surface glycoprotein. Inspection of env sequences from D1/85.16 compare...
Alternative Titles
Full title
Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41
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Record Identifier
TN_cdi_pnas_primary_106_13_5318
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_106_13_5318
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0811713106
