Calmodulin kinase II is required for fight or flight sinoatrial node physiology
Calmodulin kinase II is required for fight or flight sinoatrial node physiology
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
The best understood "fight or flight" mechanism for increasing heart rate (HR) involves activation of a cyclic nucleotide-gated ion channel (HCN4) by β-adrenergic receptor (βAR) agonist stimulation. HCN4 conducts an inward "pacemaker" current (If) that increases the sinoatrial nodal (SAN) cell membrane diastolic depolarization rate (DDR), leading t...
Alternative Titles
Full title
Calmodulin kinase II is required for fight or flight sinoatrial node physiology
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Record Identifier
TN_cdi_pnas_primary_106_14_5972
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_106_14_5972
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0806422106
