Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels
Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Proliferation of interstitial fibroblasts is a hallmark of progressive renal fibrosis commonly resulting in chronic kidney failure. The intermediate-conductance Ca²⁺-activated K⁺ channel (KCa3.1) has been proposed to promote mitogenesis in several cell types and contribute to disease states characterized by excessive proliferation. Here, we hypothe...
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Full title
Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels
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TN_cdi_pnas_primary_106_34_14518
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_106_34_14518
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0903458106
