Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal...
Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Zinc co-crystallizes with insulin in dense core secretory granules, but its role in insulin biosynthesis, storage and secretion is unknown. In this study we assessed the role of the zinc transporter ZnT8 using ZnT8-knockout (ZnT8⁻/⁻) mice. Absence of ZnT8 expression caused loss of zinc release upon stimulation of exocytosis, but normal rates of ins...
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Full title
Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice
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TN_cdi_pnas_primary_106_35_14872
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_106_35_14872
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0906587106
