Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone di...
Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease
About this item
Full title
Author / Creator
Vallet, Sonia , Mukherjee, Siddhartha , Vaghela, Nileshwari , Hideshima, Teru , Fulciniti, Mariateresa , Pozzi, Samantha , Santo, Loredana , Cirstea, Diana , Patel, Kishan , Sohani, Aliyah R , Guimaraes, Alex , Xie, Wanling , Chauhan, Dharminder , Schoonmaker, Jesse A , Attar, Eyal , Churchill, Michael , Weller, Edie , Munshi, Nikhil , Seehra, Jasbir S , Weissleder, Ralph , Anderson, Kenneth C , Scadden, David T and Raje, Noopur
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Understanding the pathogenesis of cancer-related bone disease is crucial to the discovery of new therapies. Here we identify activin A, a TGF-β family member, as a therapeutically amenable target exploited by multiple myeloma (MM) to alter its microenvironmental niche favoring osteolysis. Increased bone marrow plasma activin A levels were found in...
Alternative Titles
Full title
Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease
Authors, Artists and Contributors
Author / Creator
Mukherjee, Siddhartha
Vaghela, Nileshwari
Hideshima, Teru
Fulciniti, Mariateresa
Pozzi, Samantha
Santo, Loredana
Cirstea, Diana
Patel, Kishan
Sohani, Aliyah R
Guimaraes, Alex
Xie, Wanling
Chauhan, Dharminder
Schoonmaker, Jesse A
Attar, Eyal
Churchill, Michael
Weller, Edie
Munshi, Nikhil
Seehra, Jasbir S
Weissleder, Ralph
Anderson, Kenneth C
Scadden, David T
Raje, Noopur
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pnas_primary_107_11_5124
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_107_11_5124
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0911929107
