Dual roles of PGE₂-EP4 signaling in mouse experimental autoimmune encephalomyelitis
Dual roles of PGE₂-EP4 signaling in mouse experimental autoimmune encephalomyelitis
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS). Although prostaglandin (PG) concentrations are increased in cerebrospinal fluid of MS patients, the role of PGs in MS is unknown. We examined this issue by subjecting mice deficient in each PG receptor type or subtype to EAE induction and using agonists o...
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Full title
Dual roles of PGE₂-EP4 signaling in mouse experimental autoimmune encephalomyelitis
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TN_cdi_pnas_primary_107_27_12233
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_107_27_12233
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0915112107
