Fourier analysis and systems identification of the p53 feedback loop
Fourier analysis and systems identification of the p53 feedback loop
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
A key circuit in the response of cells to damage is the p53–mdm2 feedback loop. This circuit shows sustained, noisy oscillations in individual human cells following DNA breaks. Here, we apply an engineering approach known as systems identification to quantify the in vivo interactions in the circuit on the basis of accurate measurements of its power...
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Full title
Fourier analysis and systems identification of the p53 feedback loop
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TN_cdi_pnas_primary_107_30_13550
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_107_30_13550
Other Identifiers
ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.1001107107
