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IκBζ is essential for natural killer cell activation in response to IL-12 and IL-18

IκBζ is essential for natural killer cell activation in response to IL-12 and IL-18

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_107_41_17680

IκBζ is essential for natural killer cell activation in response to IL-12 and IL-18

About this item

Full title

IκBζ is essential for natural killer cell activation in response to IL-12 and IL-18

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2010-10, Vol.107 (41), p.17680-17685

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

IκBζ, encoded by Nfibiz, is a nuclear IκB-like protein harboring ankyrin repeats. IκBζ has been shown to regulate IL-6 production in macrophages and Th17 development in T cells. However, the role of IκBζ in natural killer (NK) cells has not be understood. In the present study, we found that the expression of IκBζ was rapidly induced in response to...

Alternative Titles

Full title

IκBζ is essential for natural killer cell activation in response to IL-12 and IL-18

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pnas_primary_107_41_17680

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_107_41_17680

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1012977107

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