Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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In yeast, Sir2 family proteins (sirtuins) regulate gene silencing, recombination, DNA repair, and aging via histone deacetylation. Most of the seven mammalian sirtuins (Sirt1—Sirt7) have been implicated as NAD⁺-dependent protein deacetylases with targets ranging from transcriptional regulators to metabolic enzymes. We report that neural-specific de...
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Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity
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TN_cdi_pnas_primary_107_50_21790
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_107_50_21790
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1016306107
