Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin h...
Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Brain-specific carnitine palmitoyltransferase-1 (CPT-1c) is implicated in CNS control of food intake. In this article, we explore the role of hypothalamic CPT-1c in leptin's anorexigenic actions. We first show that adenoviral overexpression of CPT-1c in hypothalamic arcuate nucleus of rats increases food intake and concomitantly up-regulates orexig...
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Full title
Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding
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TN_cdi_pnas_primary_108_23_9691
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_108_23_9691
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1103267108
