Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round...
Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round of mRNA translation
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
The MHC class I antigen presentation pathway allows the immune system to distinguish between self and nonself. Despite extensive research on the processing of antigenic peptides, little is known about their origin. Here, we show that mRNAs carrying premature stop codons that prevent the production of full-length proteins via the nonsense-mediated d...
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Full title
Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round of mRNA translation
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Record Identifier
TN_cdi_pnas_primary_108_28_11572
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_108_28_11572
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1104104108
