Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and hum...
Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Aggregation of amyloid-β (Aβ) as toxic oligomers and amyloid plaques within the brain appears to be the pathogenic event that initiates Alzheimer's disease (AD) lesions. One therapeutic strategy has been to reduce Aβ levels to limit its accumulation. Activation of certain neurotransmitter receptors can regulate Aβ metabolism. We assessed the abilit...
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Full title
Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans
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TN_cdi_pnas_primary_108_36_14968
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_108_36_14968
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1107411108
