Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in...
Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells
About this item
Full title
Author / Creator
Konishi, Hiroyuki , Mohseni, Morassa , Tamaki, Akina , Garay, Joseph P , Croessmann, Sarah , Karnan, Sivasundaram , Ota, Akinobu , Wong, Hong Yuen , Konishi, Yuko , Karakas, Bedri , Tahir, Khola , Abukhdeir, Abde M , Gustin, John P , Cidado, Justin , Wang, Grace M , Cosgrove, David , Cochran, Rory , Jelovac, Danijela , Higgins, Michaela J , Arena, Sabrina , Hawkins, Lauren , Lauring, Josh , Gross, Amy L , Heaphy, Christopher M , Hosokawa, Yositaka , Gabrielson, Edward , Meeker, Alan K , Visvanathan, Kala , Argani, Pedram , Bachman, Kurtis E and Park, Ben Ho
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Biallelic inactivation of cancer susceptibility gene BRCA1 leads to breast and ovarian carcinogenesis. Paradoxically, BRCA1 deficiency in mice results in early embryonic lethality, and similarly, lack of BRCA1 in human cells is thought to result in cellular lethality in view of BRCA1's essential function. To survive homozygous BRCA1 inactivation du...
Alternative Titles
Full title
Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells
Authors, Artists and Contributors
Author / Creator
Mohseni, Morassa
Tamaki, Akina
Garay, Joseph P
Croessmann, Sarah
Karnan, Sivasundaram
Ota, Akinobu
Wong, Hong Yuen
Konishi, Yuko
Karakas, Bedri
Tahir, Khola
Abukhdeir, Abde M
Gustin, John P
Cidado, Justin
Wang, Grace M
Cosgrove, David
Cochran, Rory
Jelovac, Danijela
Higgins, Michaela J
Arena, Sabrina
Hawkins, Lauren
Lauring, Josh
Gross, Amy L
Heaphy, Christopher M
Hosokawa, Yositaka
Gabrielson, Edward
Meeker, Alan K
Visvanathan, Kala
Argani, Pedram
Bachman, Kurtis E
Park, Ben Ho
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pnas_primary_108_43_17773
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_108_43_17773
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1110969108
