Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the dev...
Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance
About this item
Full title
Author / Creator
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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More information
Scope and Contents
Contents
The development of resistance to direct-acting antivirals (DAAs) targeting the hepatitis C virus (HCV) can compromise therapy. However, mechanisms that determine prevalence and frequency of resistance-conferring mutations remain elusive. Here, we studied the fidelity of the HCV RNA-dependent RNA polymerase NS5B in an attempt to link the efficiency...
Alternative Titles
Full title
Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pnas_primary_108_51_20509
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_108_51_20509
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1105797108
