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Transferred melanoma-specific CD8+ T cells persist, mediate tumor regression, and acquire central me...

Transferred melanoma-specific CD8+ T cells persist, mediate tumor regression, and acquire central me...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_109_12_4592

Transferred melanoma-specific CD8+ T cells persist, mediate tumor regression, and acquire central memory phenotype

About this item

Full title

Transferred melanoma-specific CD8+ T cells persist, mediate tumor regression, and acquire central memory phenotype

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2012-03, Vol.109 (12), p.4592-4597

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Adoptively transferred tumor-specific T cells offer the potential for non–cross-resistant therapy and long-term immunoprotection. Strategies to enhance in vivo persistence of transferred T cells can lead to improved antitumor efficacy. However, the extrinsic (patient conditioning) and intrinsic (effector cell) factors contributing to long-term in v...

Alternative Titles

Full title

Transferred melanoma-specific CD8+ T cells persist, mediate tumor regression, and acquire central memory phenotype

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pnas_primary_109_12_4592

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_109_12_4592

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1113748109

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