Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire
About this item
Full title
Author / Creator
Ostrov, David A , Grant, Barry J , Pompeu, Yuri A , Sidney, John , Harndahl, Mikkel , Southwood, Scott , Oseroff, Carla , Lu, Shun , Jakoncic, Jean , de Oliveira, Cesar Augusto F , Yang, Lun , Mei, Hu , Shi, Leming , Shabanowitz, Jeffrey , English, A. Michelle , Wriston, Amanda , Lucas, Andrew , Phillips, Elizabeth , Mallal, Simon , Grey, Howard M , Sette, Alessandro , Hunt, Donald F , Buus, Soren and Peters, Bjoern
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Idiosyncratic adverse drug reactions are unpredictable, dose-independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve immune mechanisms, and genetic association studies have identified strong linkages between drug...
Alternative Titles
Full title
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire
Authors, Artists and Contributors
Author / Creator
Grant, Barry J
Pompeu, Yuri A
Sidney, John
Harndahl, Mikkel
Southwood, Scott
Oseroff, Carla
Lu, Shun
Jakoncic, Jean
de Oliveira, Cesar Augusto F
Yang, Lun
Mei, Hu
Shi, Leming
Shabanowitz, Jeffrey
English, A. Michelle
Wriston, Amanda
Lucas, Andrew
Phillips, Elizabeth
Mallal, Simon
Grey, Howard M
Sette, Alessandro
Hunt, Donald F
Buus, Soren
Peters, Bjoern
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pnas_primary_109_25_9959
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_109_25_9959
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1207934109
