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Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and a...

Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and a...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_109_6_E353

Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia

About this item

Full title

Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2012-02, Vol.109 (6), p.1836-1837

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Carcinomas are comprised of transformed epithelial cells that are supported in their growth by a dedicated neovasculature. How the genetic milieu of the epithelial compartment influences tumor angiogenesis is largely unexplored. Drugs targeted to mutant cancer genes may act not only on tumor cells but also, directly or indirectly, on the surroundin...

Alternative Titles

Full title

Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pnas_primary_109_6_E353

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_109_6_E353

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1105026109

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